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CAS Number：1609392-27-9
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SMILES：BMS-986165, CAS 1609392-27-9BMS-986165, CAS?1609392-27-9,?Stock?1283g,?Assay?98.39%,?White powder,?Water?0.11%,?Single Impurity?0.24%.BMS-986165BMS-986165, also known as Deucravacitinib, is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM).Product Details:Name: BMS-986165CAS#: 1609392-27-9 (free base)Chemical Formula: C20H19D3N8O3Exact Mass: 425.2003Molecular Weight: 425.47Elemental Analysis: C, 56.46; H, 5.92; N, 26.34; O, 11.28Specification:Synonym: BMS-986165; BMS 986165; BMS986165; DeucravacitinibIUPAC/Chemical Name: 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamideInChi Key: BZZKEPGENYLQSC-FIBGUPNXSA-NInChi Code: InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)/i1D3SMILES Code: O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H]Appearance: White powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >3 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certifications: