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CAS Number：1628256-23-4
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SMILES：Lerociclib, CAS 1628256-23-4Lerociclib, CAS 1628256-23-4,?Stock?873g,?Assay?98.64%,?White powder,?Water?0.24%,?Single Impurity?0.32%.Lerociclib?Lerociclib , also known as G1T38, is an oral, potent and selective CDK4/6 inhibitor for the treatment of Rb competent tumors. Biochemical profiling demonstrates G1T38 is a competitive, nanomolar inhibitor of CDK4/6 with highly selectivity for CDK4-cyclin D1 and CDK6-cyclin D3. G1T38 exhibits a low EC50 (<100 nM) in Rb competent cell lines compared to >3 ??M in Rb null cells. In vivo, daily oral treatment with G1T38 causes significant, durable growth inhibition of tumors in a HER2/neu GEMM and in MCF7 xenograft breast cancer models.Product Details:Name: LerociclibCAS#: 1628256-23-4 (free base)Chemical Formula: C26H34N8OExact Mass: 474.2856Molecular Weight: 474.613Elemental Analysis: C, 65.80; H, 7.22; N, 23.61; O, 3.37Specification:Related CAS #: 2097938-59-3 (HCl)? ?1628256-23-4 (free base)? ??Synonym: G1T38; G1T-38; G1T 38; G1-T38; G1 T-38; G1 T38; LerociclibIUPAC/Chemical Name: 2'-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-oneInChi Key: YPJRHEKCFKOVRT-UHFFFAOYSA-NInChi Code: InChI=1S/C26H34N8O/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31)SMILES Code: CC(C)N(CC1)CCN1C(C=N2)=CC=C2NC3=NC=C4C(N(C5(CCCCC5)CNC6=O)C6=C4)=N3Appearance: white powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: