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CAS Number：1693758-51-8
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SMILES：IPI-549(IPI549), CAS 1693758-51-8IPI-549(IPI549), CAS 1693758-51-8,?Stock?612g,?Assay?98.84%,?White powder,?Water?0.34%,?Single Impurity?0.12%.IPI549IPI-549 is a potent and selective phosphoinositide-3-kinase (PI3K??) Inhibitor as an Immuno-Oncology Clinical Candidate (Kd = 0.29 nM). Bioactivity data of IPI-549: biochemcial IC50 (nM) for PI3K isoform: 3200 (??); 3500 (??); 16 (??); and >8400 (??) respectively. Cellar IC50 (nM) of IPI549 for PI3K isoform: 250 (??); 240 (??); 1.6 (??); and 180 (??) respectively. IPI-549 shows >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-?? mediated neutrophil migration in vivo and is currently in Phase 1 clinical evaluation in subjects with advanced solid tumors.Product Details:Name: IPI-549CAS#: 1693758-51-8Chemical Formula: C30H24N8O2Exact Mass: 528.2022Molecular Weight: 528.576Elemental Analysis: C, 68.17; H, 4.58; N, 21.20; O, 6.05Specification:Synonym: Eganelisib; IPI-549; IPI 549; IPI549.IUPAC/Chemical Name: (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamideInChi Key: XUMALORDVCFWKV-IBGZPJMESA-NInChi Code: InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1SMILES Code: O=C1N(C2=CC=CC=C2)C([C@@H](NC(C3=C(N=CC=C4)N4N=C3N)=O)C)=CC5=CC=CC(C#CC6=CN(C)N=C6)=C51Appearance: white powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months)HS Tariff Code: 2934.99.9001Certification: