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CAS Number：183499-57-2
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SMILES：L-778123, CAS 183499-57-2L-778123, CAS?183499-57-2,?Stock?945g,?Assay?98.14%,?White powder,?Water?0.37%,?Single Impurity?0.26%.L-778123L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.Product Details:Name: L-778123 free baseCAS#: 183499-57-2 (free base)Chemical Formula: C22H20ClN5OExact Mass: 405.1356Molecular Weight: 405.88Elemental Analysis: C, 65.10; H, 4.97; Cl, 8.73; N, 17.25; O, 3.94Specification:Synonym: L-778123 free base; L-778123; L 778123; L778123; L-778,123; L 778,123; L778,123;IUPAC/Chemical Name: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrileInChi Key: JNUGFGAVPBYSHF-UHFFFAOYSA-NInChi Code: InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2SMILES Code: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1Appearance: White powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certifications: