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CAS Number：2364554-48-1
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SMILES：Aficamten,?CAS 2364554-48-1:Aficamten,?CAS 2364554-48-1,?Stock?324g,?Assay?98.42%,?White powder,?Water?0.29%,?Single Impurity?0.34%.AficamtenAficamten, also known as CK-3773274 and CK-274, is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. Aficamten was designed to provide a predicted human half-life (t1/2) appropriate for once a day (qd) dosing, to reach steady state within two weeks, to have no substantial cytochrome P450 induction or inhibition, and to have a wide therapeutic window in vivo with a clear pharmacokinetic/pharmacodynamic relationship. In a phase I clinical trial, aficamten demonstrated a human t1/2 similar to predictions and was able to reach steady state concentration within the desired two-week window.Product Details:Name: AficamtenCAS#: 2364554-48-1Chemical Formula: C18H19N5O2Exact Mass: 337.1539Molecular Weight: 337.38Elemental Analysis: C, 64.08; H, 5.68; N, 20.76; O, 9.48Specification:Synonym: Aficamten; CK-3773274; CK3773274; CK 3773274; CK-274; CK274; CK 274;IUPAC/Chemical Name: N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-pyrazole-4-carboxamideInChi Key: IOVAZWDIRCRMTM-OAHLLOKOSA-NInChi Code: InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1SMILES Code: O=C(C1=CN(C)N=C1)N[C@@H]2CCC3=C2C=CC(C4=NOC(CC)=N4)=C3Appearance: Solid powderPurity: >98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: Soluble in DMSOShelf Life: >2 years if stored properlyDrug Formulation: This drug may be formulated in DMSOStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certification: