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CAS Number：2109704-99-4
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SMILES：Belumosudil mesylate, CAS 2109704-99-4Belumosudil mesylate, CAS?2109704-99-4,?Stock?211g,?Assay?99.14%,?White to off- white powder,?EOS Med Chem is big manufacturer of Belumosudil mesylate.Belumosudil mesylateBelumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 ?M, respectively). Belumosudil (SLx-2119; 40 ?M) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. It is used in the treatment of Autoimmune Diseases. Belumosudil was approved in 2021 in USA To treat chronic graft-versus-host disease after failure of at least two prior lines of systemic therapyProduct Details:Name: Belumosudil mesylateCAS#: 2109704-99-4 (mesylate)Chemical Formula: C27H28N6O5SMolecular Weight: 548.62Elemental Analysis: C, 59.11; H, 5.14; N, 15.32; O, 14.58; S, 5.84Specification:Related CAS #: 911417-87-3 (free base)? ?2109704-99-4 (mesylate)??Synonym: Belumosudil mesylate; KD 025; KD-025; KD025; WHO11343; WHO-11343; WHO 11343; SLx 2119; SLx2119; SLx-2119;IUPAC/Chemical Name: 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(propan-2-yl)acetamide methanesulfonate (1:1)InChi Key: ILQJXEIRBCHLOM-UHFFFAOYSA-NInChi Code: InChI=1S/C26H24N6O2.CH4O3S/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22;1-5(2,3)4/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31);1H3,(H,2,3,4)SMILES Code: O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1.CS(=O)(O)=OAppearance: Solid powderPurity: >99% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Solubility: To be determinedShelf Life: >2 years if stored properlyDrug Formulation: To be determinedStock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).HS Tariff Code: 2934.99.9001Certifications: