Biggest Nazartinib 1508250-71-2 supplier, stock 1.8kg

May 16, 2019

Biggest Nazartinib 1508250-71-2 supplier, stock 1.8kg

2019 CHINA CPHI  E2A62
2019 WORLD CPHI 101C45


Biggest Nazartinib , 1508250-71-2 supplier, stock 1.8kg

Nazartinib, also known as EGF816 and NVS-816, is an orally available, irreversible, third-generation, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. EGF816 covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGF816 preferentially inhibits mutated forms of EGFR including T790M, a secondarily acquired resistance mutation, and may have therapeutic benefits in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors.

Nazartinib Intermediate: Pilot scale Intermeidates: 1032684-85-7, 1508258-34-1.

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Name: Nazartinib
CAS#: 1508250-71-2
Chemical Formula: C26H31ClN6O2
Exact Mass: 494.2197
Molecular Weight: 495.02
Elemental Analysis: C, 63.09; H, 6.31; Cl, 7.16; N, 16.98; O, 6.46

Synonym: EGF816; EGF-816; EGF 816; NVS-816; NVS 816; NVS816; Nazartinib.

IUPAC/Chemical Name: (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide


InChi Code: InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1


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2019 CHINA CPHI  E2A62
2019 WORLD CPHI 101C45
Clinical Phase II, III Intermediates
GMP Custom synthesis, Full Document

R&D Center: 8000 sq, More than 100 hoods
Pilot Plant: 20000sq, 40 reactors from 5-200L
Manufacturing Site: 800000sq, 40 reactors from 100-5000L